The Relationship Between Thyroid Dysfunction and Sleep Quality Among Population of Saudi Arabia (2024)

Associated Data

Data Availability Statement

Abstract

Keywords: thyroid disorder, sleep quality, PSQI, Saudi Arabia, patient care

Introduction

People sleep for roughly one-third of their lives. There is evidence from studies that abnormal sleep patterns are associated with a variety of conditions, including thrombotic disease, epilepsy, arthritis, psychiatric disorders, chronic pain, and diabetes.^1–4 The most prevalent sleep-related breathing disease is obstructive sleep apnea (OSA), which poses a significant public health concern when left untreated because of the underlying comorbidities.⁵

Despite the fact that there is a correlation between thyroid issues and irregular sleep patterns. Problems sleeping may be caused by a number of different ailments, and some of the symptoms of thyroid disorders, such as weariness or difficulties falling asleep, might overlap with sleep problems that are caused by other conditions. Thyroid issues may have an impact on the quality of sleep due to a number of different variables. In most cases, thyroid function is assessed by the use of blood tests to determine the levels of hormones.^6,7 The quantity and quality of sleep are crucial for maintaining normal function. Additionally, it aids in the management of hunger and supports the preservation of regular metabolic and hormonal processes. Sleeping for fewer than 6 hours a day is linked to abnormalities in energy metabolism, according to some studies. This suggests that sound sleep is essential for the control and discharge of thyroid hormones. Other metabolic conditions like obesity, insulin resistance, and diabetes are linked to sleep deprivation and circadian clock disruption. With a weight of between 20 and 30 grams in adults, the thyroid gland is one of the biggest endocrine glands in the human body. It is composed of two lobes that are linked inside each other.^8–16 There is an incidence of between 4% and 7% for thyroid lesions, which are often detected on the gland. The vast majority of individuals do not exhibit any symptoms, and their thyroid hormone secretion is typical.¹⁷

The relation between hormones and sleep has been acknowledged for quite some time. Research findings suggest that profound sleep significantly impacts the endocrine system. For instance, profound sleep is associated with increased secretion of prolactin (PRL) and growth hormone (GH). It is well acknowledged that obesity is a risk factor for the development of comorbid disorders, including but not limited to cardiovascular disease, type 2 diabetes mellitus, cancer, asthma, osteoarthritis, chronic back pain, obstructive sleep apnea, non-alcoholic fatty liver disease, and gallbladder diseases.¹⁸ In contrast, cortisol and thyrotropin secretion is diminished. Levels of ACTH often rise in response to a decrease in cortisol levels. In the hypothalamic-pituitary-adrenal (HPA) axis, there is a feedback loop that is responsible for this phenomenon. There exists empirical evidence indicating that disruptions in sleep integrity can induce alterations in the circadian rhythm, which subsequently impact the inflammatory system. The thyroxine (T4) and triiodothyronine (T3) thyroid hormones induce physiological changes in the metabolism of every tissue.^19–23

Thyroid hormones, T3 and T4 alter the physiology of every tissue’s metabolism. T4 and T3 secretion from the thyroid gland is regulated by pituitary thyroid-stimulating hormone (TSH) and hypothalamic thyrotropin-releasing hormone (TRH). Sleep disturbances have the potential to disrupt the operation of the hypothalamic-pituitary-thyroid axis in humans, and are correlated with fluctuations in TSH, T4, and T3 levels. A correlation has also been observed between excessive sleep deprivation and subclinical hypothyroidism.

Because thyroid diseases and sleep disorders are two of the major health issues in Saudi Arabia with a wide variety of clinical spectrum, we aim in this observational study is to assess the relationship between these two major clinical factors and to establish baseline incidental findings among the population of Saudi Arabia.

Materials and Methods

This study employed an observational cross-sectional design and included a representative sample of the Saudi Arabian population. The designated demographic was given a self-administered digital questionnaire. The questionnaire contained sociodemographic variables (such as age, gender, marital status, education, etc.) and the Pittsburgh Sleep Quality Index (PSQI) to evaluate the participants’ sleep quality. The translation of the questionnaire is validated and the study complies with the Declaration of Helsinki. All participants provided informed consent.

Results

The statistical significance level was set at p<0.05. The statistical software SPSS edition 26 (Armonk, NY: IBM Corp., USA) was used to analyze all the statistical data. In total, one thousand and forty-four completed questionnaires were received. Table 1 describes the socio-demographic characteristics of participants. 54% were aged between 21 and 30 years old, with nearly two-thirds (62%) being females. Most of the respondents were Saudis (85.1%), and 40.2% lived in the Western Region. Approximately 67.9% of the respondents were single, and 71.4% were bachelor’s degree holders. Respondents who were students constituted 53%. The prevalence of participants who had been diagnosed with thyroid disease was 9.2%, and the most common type of thyroid disease was hypothyroidism (60.4%). In Table 2, a higher mean score can be seen in the sleep latency component (mean score: 1.62), followed by sleep disturbance (mean score: 1.45) and sleep efficiency (mean score: 1.45), while the least was the sleep medication component (mean score: 0.27). Additionally, Figure 1 represents the prevalence of poor sleep quality among the study participants, as assessed by the Pittsburgh Sleep Quality Index (PSQI). The overall mean PSQI score was 8.17 (Standard Deviation (SD) 3.56). When comparing patients with or without thyroid disorder, it was found that participants with thyroid disorder were more associated with higher mean scores in sleep disturbances (p=0.001), sleep medication (p<0.001), and global PSQI (p=0.001). When measuring the relationship between sleep quality and the socio-demographic characteristics of participants (Table 3), it was revealed that the prevalence of respondents who had poor sleep quality was significantly more common among gender females (p=0.006), those who had better education (p=0.020) and those who had been diagnosed with thyroid disease (p=0.010). A multivariate regression model (Table 4) revealed that gender females and diagnosis of thyroid disease were the independent significant risk factors for poor sleep quality. This further suggests that compared to gender males, gender females were predicted to increase the risk of poor sleep quality by at least 1.4 times higher (AOR=1.412; 95% CI=1.057–1.886; p=0.020). Respondents diagnosed with thyroid disorder were 2 times as likely to develop poor sleep quality as compared to patients who do not have thyroid disease (AOR=2.006; 95% CI=1.094–3.678; p=0.024). However, the educational level did not significantly affect poor sleep quality after adjustment to a regression model (p=0.056).

In this study, we want to arrive at results that are applicable to a specific demographic. In the event that a particular component, such as a specific sleep problem, has a relatively low distribution among the research group, it is possible that the conclusions associated with that factor cannot be generalized to the whole population. For instance, if the research only comprises young persons, the results on sleep apnea, which is more prevalent in elderly people, could not be applicable to the general population.

In order for statistical tests to be accurate, they need a certain number of observations to be collected within each category (for example, excellent sleep vs poor sleep). It is possible that there are not enough data points in a particular category to carry out an analysis that is statistically sound if a factor has a distribution that is very low. It is possible that this will result in equivocal findings or an increased likelihood of Type II errors, which are mistakes that fail to identify a real effect. The researchers could change their attention to elements that have a more equal distribution among the population in order to arrive at a result that is more generalizable if the study question permits it.

Discussion

This study sought to measure the relationship between thyroid disorder and sleep quality. Our study showed that there was a significant relationship between thyroid disorders and poor sleep quality. Notably, based on PSQI criteria, sleep disturbances, sleep medication, and overall PSQI scores were all statistically significantly higher in participants with thyroid disorders (p<0.05). This is comparable to the study of He et al²² reporting a significantly higher PSQI score, particularly among differentiated thyroid cancers (DTC), and they were also seen to have a higher prevalence of poor sleep quality than any other group. Another study done by Nazem et al²³ noted a significant increase in thyroid function tests such as thyroxine (T4) and thyroid stimulating TSH in patients with poor sleep quality. In addition, they found significant links between poor sleep conditions in relation to sleep score, free thyroxine (FT4), and stress score, suggesting poor sleep quality negatively impacted thyroid hormones. Similarly, Kim et al²⁴ documented an association between short sleepers and subclinical hypothyroidism (SHYPO), indicating that both longer and shorter sleep durations were associated with an increased risk of subclinical thyroid dysfunction. Contradicting previous reports, several studies documented no association between thyroid dysfunction and sleep quality. For example, Feng et al,¹² found that TSH levels, serum-free triiodothyronine (FT3), and FT4 did not significantly affect children with obstructive sleep apnea-hypopnea syndrome (OSAHS) before and after endoscopic adenoidectomy. This was also documented by the studies done in USA²⁵ and in Turkey,²⁶ wherein OSA showed no significant relationship with subclinical or prior hypothyroidism.

Data from our study suggest that female gender and thyroid disorder diagnosis were the independent significant risk factors for poor sleep quality. In China,¹⁹ studying patients with SHYPO, they also detected women with younger age and lower body mass index were at significant risk for having poor sleep quality. Incidentally, in a conducted among patients with DTC,²⁷ they found that the Insomnia Severity Index (ISI) was significantly correlated with various Thyroid-specific Patient-Reported Outcome (ThyPRO) scales, with anxiety and emotional susceptibility being the most correlated significantly with PSQI and ISI. In a large study done by US National Health and Nutrition Examination Survey between 2007 and 2008,²⁸ after adjustment to confounders, respondents on thyroid hormone replacement were predicted to increase the risk of sleep apnea (SA) diagnosis by at least 2.51 times higher compared to euthyroid subjects, while respondents with elevated TSH who were not taking medication were predicted to have decreased risk of SA diagnosis. In a report published by Song et al¹⁹ they found that subclinical hypothyroidism (SHYPO) patients have significantly higher total PSQI scores than euthyroid patients (control group), and they were likewise associated with longer sleep latency, shorter sleep duration, and poorer sleep quality.

Notably, our results indicate that the prevalence of poor sleepers was relatively high, constituting 75.7%. Among those who had been diagnosed with thyroid dysfunction (n=96), the prevalence of poor sleepers was 86.5% (p=0.010). This result is slightly higher than the study of Nazem et al,²³ reporting a prevalence of low sleep quality of 49.4%. However, among patients diagnosed with OSA,²⁹ evidence suggests that subclinical hypothyroidism was more common among this group of patients, but the number of OSA patients who were newly diagnosed with clinical hypothyroidism was minimal. Moreover, the proportion of patients with thyroid dysfunction was relatively low in this investigation, considering the whole study population.

Conclusion

The purpose of this observational study was to clarify how Saudi Arabian population thyroid disorders and sleep quality are related. According to our research, a significant proportion of participants (75.3%) reported having poor quality sleep, which is significantly correlated with being diagnosed with a thyroid condition and being female. Interestingly, our analysis showed that people with thyroid disorders were more likely to have sleep disturbances, as indicated by higher Pittsburgh Sleep Quality Index (PSQI) scores, especially in the areas of sleep disturbances, use of sleep medications, and overall PSQI scores. Particularly noteworthy is the significant impact of thyroid disorders on sleep latency, sleep disturbances, and duration in our study cohort. This provides important insights into the complex nature of thyroid disorders and their implications for day-to-day functioning. It is essential to recognize the limitations of our research, chief among which being the dependence on self-reported data that could potentially introduce biases. This emphasizes the need for additional investigation using a wider range of approaches in order to confirm and build upon our results. Subsequent research endeavors ought to focus on defining the mechanisms that underlie the correlation between thyroid function and sleep quality. This may involve investigating interventional strategies aimed at ameliorating the deleterious impact of thyroid disorders on sleep. Eventually, this study adds to the increasing amount of research that shows a connection between thyroid dysfunction and inadequate sleep quality. It highlights the necessity for medical practitioners to treat patients with thyroid disorders holistically, taking into account the possible effects on sleep and general quality of life. Our results highlight the value of a multidisciplinary approach in treating complex, interrelated health issues and support the inclusion of sleep quality assessment in the management of thyroid disorders. To fully understand this relationship and open the door to more complete, effective treatment options, more research in this area is essential.

Acknowledgments

The authors would like to show sincere thanks to those techniques who have contributed to this research.

Data Sharing Statement

The experimental data used to support the findings of this study are available from the corresponding author upon request.

Ethical Approval Statement

The study was approved by the review committee of our ethics committee. All patients and their families gave informed consent. The study adheres to the principles outlined in the Declaration of Helsinki. Title:“The relationship between thyroid function disorder and sleep quality among population of Saudi Arabia” has been reviewed and approved by the Research Ethics Committee (REC) at University of Hail dated: 11/9/2023 under the reference number H-2023-362.

We thus consent to the oversight and examination conducted by the Ethics Committee. Moreover, we guarantee the veracity and comprehensiveness of all the information supplied inside this application.

Disclosure

The authors report that there are no competing interests in this work.

References